Homemade Sodium Butyrate Enemas Work for UC

It’s been a while since I updated this blog. In fact, I’ve been feeling so well lately, I’ve been busy working on three projects at once, however, stay tuned for a lot more articles in the future.

Here’s a major breakthrough: I had a brief flare of ulcerative colitis a few months ago but was able to halt it with homemade retention enemas. They each contain only 4 ounces of water with a blend of probiotics (bifido infantis)  and sodiium butyrate. I’d read studies that showed butyrate to be effective for UC and was surprised to find you can purchase it easily here.

The recipe is easy: I mix 4 capsules sodium butyrate with distilled water, in an emptied and rinsed Fleet Enema bottle. The probiotics are optional, but bifido infantis has been proven to reduce inflammation in quite a few studies. During the active flare I did the enemas morning and night, and as I healed I reduced them to once per day. For me, it took about a week, and soon I was no longer bleeding. That’s faster than steroid enemas,  or even oral or IV steroids.

Butyrate also has no side effects, such as bone loss from prednisone, or lymphoma from Imuran and 6-mp, and depending on your nutrient needs, a few other types of butyrate are sold, such as potassium butyrate or cal/mag butyrate. I’ve experimented and they are all very effective.

How does SB work? It appears to help the body generate protective mucus, and is an energy source for the cells of the gut wall. Not surprisingly, sodium butyrate as been found to have potent antifungal properties. This means it can help kill candida in the colon. Before trying it for any condition, I’d say it’s best to talk to your doctor. My GI was familiar with the treatment and supportive.

In other news, as far as food intolerances go, I’m able to eat about 75% of my former full diet these days, and it’s possible some of the problem foods could be reintroduced right now, but I feel good enough as-is I don’t want to rock the boat. I now weigh 162 lbs, which is right where I was during college years, for the bulk of my healthy life.

Recently I’ve been eating full-fat, organic yogurt, every other day. The brand I’m trying is Nancy’s, because it’s got lots of L. rhamnosus in it, which has been proven in several studies to help with depression/anxiety. My only suggestion would be to not go overboard with it, since yogurt has enough lactose to feed candida in the gut.

Everything I’m doing now is improving constipation, which in turn is boosting my energy levels quite a bit. At work, I’m flying up and down long hallways, feeling lots of strength in my legs. I’m still have some fatigue, as standing for long periods is tiring, but things are definitely moving in the right direction.

Has anyone else tried sodium butyrate enemas? If you’ve got feedback for me, or if you want to learn more about how to use this simple therapy, I’d love to hear from you in the comments section.


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13 thoughts on “Homemade Sodium Butyrate Enemas Work for UC

    • yes, this is an excellent page, john! i’ve noticed for the last few years that when i’m feeling my blood pressure rising, and am in a high-sypathetic state, simply running my hands under warm water (not hot) from the tap is enough to trigger my parasympathetic activity. the effect is immediate!

      Liked by 1 person

    • perhaps simplest of all, and requiring access to no “tools” is to breathe out for a count of 4, and in for a count of 3. this is hard to do if in the heat of “battle”, dealing with an immediately stressful situation, but it’s quite effective in the aftermath. 🙂


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  5. John
    I have a rectal stump w UC flare in it post illeostomy. As I was reading on many sites byturate is an excellent treatment for practitis so I contacted a compounding pharmacy and got byturate suppositories.
    When I inserted one I felt excruciating burning sensation? ! Could not hardly Stan it.. is it comon w byturate? HAVE YOU Heard OR Experienced Burning OR Stinging w an enema you ve been using?
    Thank you. Appreciate your comments as I’m desperately seeking relief.


    • Hi, John – sodium butyrate on its own is fairly salty. i wouldn’t want to use it undiluted with distilled water, and the ratio i used for my last flare (months ago now, thankfully) is about 4 – 600mg capsules per 4.5 oz distilled water. you could try just 1 or 2 capsules if 4 is irritating, but i’m pretty sure if you create a solution instead of using it in its pure state you’ll be fine. keep us posted if you can. 🙂


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