Lufenuron: Healing Chronic Fatigue & More

A month or so ago I was feeling “okay” but not great. Ever since I was given Levaquin antibiotics in the ER for food poisoning, about 4 years ago, I’ve had CFS/ME, brain fog, tinnitus, POTS, SIBO, food intolerance, asthma, ulcerative colitis, sinus and skin issues, depression/anxiety, rising blood sugar and constipation.

Does this sound familiar to any of you? What’s the common thread?

I’ve had fungal overgrowth, inside and out, for years, made much worse by broad spectrum antibiotics. Doctors shuffle me out of their offices when I ask for Nystatin powder, or other prescription antifungals, despite having obvious plaques on my scalp, feet, face, chest and groin, plus sinus and lung irritations consistent with candidiasis.

I have tried my best to control it with diet and herbals, like olive leaf, pau d’arco, grapefruit seed extract and berberine. It’s a chronic infection, so I’m slowly feeling worse and worse. Recently, even downing healthy amounts of cultured veggies and homemade kefir (both are powerful probiotics) hasn’t been very effective.

Flash back to a month ago, all it took was one starchy lunch that fed candida and i got horribly ill. I had GERD, muscle spasms, insomnia, asthma. In the days that followed, I knew I needed to do something more drastic to get the upper hand. Colloidal silver was helpful, but not something I wanted to take longer term. I heard about Lufenuron in an online forum. Not for human use, this chitin-inhibitor dissolves flea eggs, and… the outer shell of candida. Mammals don’t have chitin, so it’s apparently safe for dogs, cats and (theoretically) people.

It’s typically given for the first week of every month, daily, with a high fat meal (so it will deposit in tissues and be slow-released, rather than quickly leaving via the GI tract), then for the remaining 3 weeks of each month it goes to work destroying fungal overgrowth.

gorilla

Yes, humans aren’t supposed to use it, but there’s nothing stopping anyone from treating their gorilla, so that’s what I set out to do. Curiously, ever since i gave my pet ape pure Lufenuron, we both started to feel much better.

This is my record of that adventure, which will be updated periodically:

Day 1: dosage was 2 grams, and by the middle of Day 2, a major burst of mental clarity occurred. By that evening, the ability to sleep deeply had returned, to the point of waking on Day 3 — after 10 hours with no dreams, out like a light — and muscles felt much less sore, plus joint pain had disappeared.

To reiterate: during a 7 day total treatment “loading” window, 2 grams were administered daily, with a high-fat meal.

By Days 4 and 5, die-off symptoms emerged, which is not surprising, and lasted until Day 12: diarrhea, blurred vision, fatigue, insomnia and body aches. The good news: no more constipation, but it took 10 days for die-off to subside, and detoxing continues.

Day 13: colon inflammation is gone, and a healthy, sometimes ravenous appetite has emerged. I’m finding I don’t have to manipulate my neck as much to relieve POTS symptoms. I also think my tinnitus is a little better. It comes and goes, but I have more moments of silence.

Today, Day 14, upon waking, the gorilla is quite spunky, feeling like a randy teenager (Lufenuron might replace Viagra), and in the afternoon, muscles unwind in a characteristic activation of the parasympathetic nervous system, as nap time beckons. The vagal nerve is working now, which is intriguing! Was candida to blame for it running amok? It’s amazing how long, hot showers are enjoyable again (for my monkey). Relaxation is happening; anxiety is disappearing. There’s no more being stuck in fight-or-flight mode.

Healing like this is emotional, but “joy” hasn’t returned yet. My gorilla is still waiting for that.

By the way, people should not treat their primate’s flea problem with pure Lufenuron unless they’ve consulted a veterinarian, and should never treat themselves using medication not approved for humans. In fact, any and all new treatments contemplated should first be discussed with a physician. Please see the disclaimer.

With that said, CFS symptoms are improving, POTS also, along with so much more. Go, monkey, go.

To be continued.

UPDATE: I tried Lufenuron three times, and while the first dose provided incredible relief, when I took it again one month later it was only half as effective as it had initially been, and by the third dose, another month after that, it barely had an impact on my fungal overgrowth at all. This was despite mixing it with herbals.

Luckily I learned something valuable from the experiment: it seemed my immune system was the problem, so I began looking for something that could boost my body’s innate ability to fight candida. That led me to iodine, and a potential connection between fluorquinolone antibiotics, like Cipro and Levaquin, and hypothyroidism. Here’s the first installment of my iodine protocol. You’ll find the second article here. So far the results have been really encouraging, and unlike Lufenuron, iodine is both inexpensive and subject to much greater testing in humans.

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Candida, SIBO and… Silver?

A brief bit of background: my mother took lots of antibiotics, from the 1950s onward, and was on Tetracyline when pregnant. I got my gut flora from her, as anyone would, but was born prematurely and spent 2 months in an isolette. This means I acquired the rest of my microbiome in a hospital, before heading home. I think it’s safe to say I’ve have had yeast issues for most of my life. My entire family did.

The standard medical attitude about candida continues to be “it doesn’t exist in anyone unless they are immune compromised”. My gut flora was damaged pre-birth, then I had a family doctor who prescribed antibiotics for a simple cough, or the sniffles, I’ve since been hit with Cipro and Levaquin (fluoroquinolone antibiotics) at least a dozen times, so from a modern understanding of gut-immune function, I am immune-compromised!

I got toenail fungus at an early age, developed sinus trouble (more antibiotics!) and have since read reputable sources saying most sinus issues are fungal. Candida? Maybe so, but the type of fungus is moot. Next I got asthma, seasonal allergies, then ulcerative colitis, then severe food intolerance. At no point along that path did any doctor say I needed to heal my microbiome, or go on a paleo diet, so if they didn’t understood something so basic, I can’t put much stock in their wholesale dismissal of candida overgrowth.

Here’s the good part — I’ve been getting better ever since I started paying attention to gut health. It’s simple. Lower carb is healing — sugar is bad. Probiotic foods are a “yes” — antibiotics are an emphatic “no” (unless utterly essential). It’s been a wonderful road back for me, with every single health condition.

I’ve recently discovered antibiotics very likely destroyed the fragile, butyrate-producing bacteria in my gut, and butyrate heals inflammation  — while also being anti-fungal. No wonder homemade sodium butyrate enemas have been so helpful for my ulcerative colitis flares. I believe butyrate could certainly help others with IBD, including Crohn’s disease. It may even play a role in protecting the upper gut (small intestine) from development of SIBO. Speaking of…

Early this week, a Monday, I’d just started a new job. I didn’t have time to fix my own lunch from home, so I had to fend for myself in the usual higher-carb, sugary restaurants. I found a beef roast with sides. The meat portion was tiny, covered with a sweet gravy. Roasted potatoes and green beans rounded it out, but that same sauce was all over the veggies. I was so hungry I ate every potato. Normally only eat about 3 oz of them a day. I’d been in good shape, gut-wise, for so long, I could afford to cheat, right? Wrong! By morning, I could tell I had yeast overgrowth. My gut had zero peristalsis, I had bad tinnitus, which for me is usually a sign of SIBO returning, my breathing was restricted, sinuses were inflamed, and energy was in the tank.

I’d had had such luck with yogurt, in recent weeks, I decided to eat two pints, the following day at work. Apparently the candida had done such a job slowing down my gut, the yogurt just sat there. Candida has been slowly digesting us since day one. I believe it uses “host manipulation“, which is what many successful parasites do. People with yeast overgrowth often crave sweets and alcohol. I know I have in the past, and I didn’t lose that until I started removing yeast from my body.

Hyphal Form Candida

It makes sense: if candida creates sweet tooths to feed itself, why wouldn’t it also emit chemicals to slow down gut transport, to more effectively eat our food? This may explain why so many of us are underweight, or constipated, and could be a strong hypothesis for alcoholism. Here’s a very interesting thread exploring a connection between SIBO and candida. Normally benign, its invasive (hyphal) form is thought to just be a symptom of dysbiosis. A healthy array of commensal bacteria should curb overgrowth. However, for those who’ve had hyphal form for decades, we need to deal with it.

I am hosting hookworm right now, for food intolerance, asthma, IBD, so I can’t take oregano oil, olive leaf, berberine, even peppermint, without killing them. Colloidal silver is an antibiotic, but it will just stun them for a few days.  Numerous articles discuss a rare condition called agyria, where people who consumed massive amounts of silver turned their skin a bluish tint. I have taken only 3 courses, a few weeks at a time, in the last 4 years. I’m not worried about changing color!

So back to the problem at hand, by the end of day 2 my entire back was sore, where it was nearly impossible to walk. I have a specific pull-pattern where one rib gets dislocated, and it happens most often when my gut is unhealthy. Lipopolysaccharide, a bacterial endotoxin, may be the root of this inflammation. That night, I simply couldn’t find any position to lie in, and insomnia made everything worse. I spiked a fever from the SIBO, which is rare for me, and my lungs felt like bronchitis was developing.

Most people would have gone to the doctor at this point, and been prescribed antibiotics, but I don’t tolerate most of them, and would rather use an antimicrobial that kills both bacteria and yeast.

The morning of day 3, I still had a fever, and started with 1 ounce of 500 ppm (parts per million) colloidal silver in a pint of distilled water, which makes it about 33 ppm. This is a safe level, in my opinion, especially since I take it very rarely. It has had a long history as an antibiotic before the modern pharma-industry developed conventional antibiotics. Here’s a study showing silver’s effectiveness against antibiotic-resistant strains. I’ve read other sources claiming it “smothers” both good and bad bugs. Its effect on candida is confirmed by several studies.

To deal with my lungs I used 30 ppm silver in a miniature glass spray bottle. 5 puffs every two hours. So how did it all go? Interestingly, the oral silver seemed to get my gut moving, and my stools were soft but formed. I’m thinking this relates to a lower yeast population in the gut. A few hours after starting inhalation, my lungs were clear, the fever broke, and I’m still feeling pretty good. I’ve read articles where doctors used CS in a nebulizer to treat people with AIDS-related lung infections, so this seems like a solid approach. It protects weak patients like me (who are immune compromised) from gut-damaging systemic antibiotics.

What’s my takeaway? Buying silver is expensive, and I normally make my own, using a cheap generator, that tests out about 17 ppm. The cost of home-brewed is pennies per pint. I plan to use the silver orally and as a spray mist only if needed, for the next few days, then I’ll go back to cultured foods like homemade kefir, raw sauerkraut. Silver is best used sparingly. I prefer adding healthy flora to my gut, not killing friend and foe alike. I also take Prescript Assist, VSL #3, and LifeStart powder now, as probiotics, plus an occasional butyrate enema. This is what works, and I’ll keep it up, but perhaps the moral to this story is, the next time I’m late for work, I’ll stop and cook my own, sugar-free, lower-carb lunch!

PS: for those interested in learning more about colloidal silver, here’s a great group on Facebook: Colloidal Silver, Pro & Con, where all points of view are appreciated. And keep in mind all the usual caveats apply: ask your doctor before trying any new therapy.