Heal Type 2 Diabetes with a Probiotic?

Recently, I’ve discovered the joys of butyrate for gut inflammation, when it stopped my last ulcerative colitis flare faster than steroids or Imuran, but it’s clear this short chain fatty acid (SCFA), which is created by gut bacteria as they ferment mostly vegetable fibers, is critical to protecting against colon cancer, leaky gut, and a variety of other conditions. What if anti-fungal, anti-inflammatory butyrate is also the key to healing diabetes, or rather, what if an absence of butyrate-generating gut flora may lead to dysregulation of blood glucose, and what if we could fix this?

Enter Clostridium Butyricum, a Japanese probiotic by the name Miyarisan Tablets, that actually generates butyrate! Of course it makes sense this soil-based bacteria might also heal ulcerative colitis, but it has another wonderful feature: its ability to guard against deadly c. diff infections. In Japan, many people are given c. butyricum upon entry to a hospital, as a preventative for these dangerous and highly-contagious acquired infections. Yes, this probiotic is a true powerhouse.

Clostridium_butyricum

Back to metabolic issues, I read an article on Chris Kresser’s site where he noted low carb dieters tend to have higher blood glucose levels, because of induced insulin resistance. Here’s an additional hypothesis: I wonder if people with damaged flora seek out a paleo diet, since it’s less likely to aggravate their GI symptoms of carbohydrate intolerance. Furthermore, ancestral diets (in practice) tend to be higher in fats and animal protein and lower in vegetable fibers, so it makes sense these people would start out deficient in butyrate-generating flora, pre-paleo (perhaps due to antibiotics use or inherited altered flora), and continue to limit their butyrate generation through lower consumption of vegetable fibers. A growing interest in resistant starches seeks to address this, with dietary hacks that increase butyrate.

Are higher than normal fasting glucose levels static, or over a longer time frame are these people at risk for developing diabetes? And what if someone is already diabetic? Generally, low carb diets work for managing type 2, and resistant starch gets high marks for improving metabolic profiles, bifido strains or not. We’ve known for quite a while that cultured foods improve diabetes by limiting carbohydrate metabolism. Leading edge research is now figuring out gut flora transplants might even heal diabetes. But what if simply establishing a colon full of c. butyricum could provide some of these same benefits?

Another approach would be to use a probiotic developed for IBD, VSL #3, to brew a yogurt, which would boost the ranks of bacteria substantially and also make it totally active. Here’s a study that shows VSL #3 was both effective in increasing glucose tolerance and generating more butyrate. VSL is more complex than Miyarisan. It lists streptococcus thermophilus, bifidobacterium breve, bifidobacterium longum, bifidobacterium infantis, lactobacillus acidophilus, lactobacillus plantarum (abundant in sauerkraut), lactobacillus paracasei, and lactobacillus delbrueckii subsp. bulgaricus. When making a yogurt from this, it’s assumed these ratios would change, as not all bacteria would have the same growth rate in milk.

While it’s not likely to be a cure, could therapeutic doses of c. buytyricum,  or the blend of strains in VSL #3, halt rising glucose levels, or even improve numbers?

I aim to find out. My fasting glucose used to be perfect, but have been creeping higher since taking courses of fluoroquinolone antibiotics, like Cipro and Levaquin. Anyone can monitor their levels, using a glucose meter, so it should be easy to track results. I’ll try the Miyarisan Tablets in combination with VSL#3 in a ferment, for increased viability, and will be eating my tried and true resistant starches, which should boost good ole butyrate. Along the way, I predict ulcerative colitis will be banished from my gut, since I’ll be a prolific butyrate auto-generator for the first time in many years. Stay tuned!

Are you pre-diabetic or diabetic, and experimenting with probiotic foods and resistant starch? Do you use butyrate supplements for ulcerative colitis or crohn’s? I’d love to hear from you in the comments section, or at GHN on Facebook. We also have a dedicated group on Facebook for Healing or Avoiding Diabetes by Fixing the Gut. Thanks! 🙂

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GHN – Changing Things Up a Bit! :-)

Hello, everyone! Going forward, I’m planning to shift the format here at GHN to include shorter posts with links to breaking news related to the microbiome, and strategies for improving GI health. These will include related studies, whenever possible, and interconnected ideas from all the”self-experimenters” in our (rapidly expanding!) networks.

I realize many use this blog as a resource for troubleshooting your own health issues, and I want all of us to be able to A) cover a lot of ground, and B) reach our own conclusions.

I’ll continue to post articles about my own adventures with helminthic therapy (specifically necator americanus hookworm) cultured foods, various antimicrobials, and FMT, as events unfold and updates are warranted.

I am appreciating all your feedback, and wish WordPress was designed as a more interactive format. Comments tend to get buried in these blogs, visually, and that limits discussion, but please DO keep up your replies so we can all continue to learn from each other. 🙂

Lemongrass Oil for Deep Acne

Did you always have clear skin before your gut health changed? Have you noticed the more vegetables you eat, and especially when combined with carbs, like rice and potatoes, the more likely you are to get deep acne, or rosacea, especially to each side of the nose, about 24 hours after eating the offending food?

This has certainly been my experience, and the acne/rosacea/gut connection is a strong one. Sometimes, doing a probiotic retention enema will reduce the inflammation quickly enough to avoid a breakout, but if I can’t catch it in time, the next best thing I’ve found for deep acne is applying organic Lemongrass oil. Sometimes the pimple can be resolved virtually overnight.

lemongrass

Rather than using it undiluted, which may burn skin, I dilute it 1:4 with a carrier oil, like Jojoba, which can also be found as an organic product. This is the strength I use as a spot treatment, overnight. It’s capable of healing even deep, adult acne. For a facial wash, try 1 drop Lemongrass oil to 50 drops 30 ppm colloidal silver, which is antibacterial and antifungal, and mist on before bed using a pump-spray bottle.

Note: anyone using these oils for the first time should apply a drop of it, diluted 1:4 as you would use on your face, to an area like the wrist, where it can be easily washed off in the event of any irritation. People with sensitive skin, be sure to ask your dermatologist. Topical use of colloidal silver is quite safe, and highly effective against yeasts and fungi, but one should pay attention to dosing guidelines for silver.

The approach outlined above is for acute flares of acne. By far the best longer term treatment, for most people, is to heal your gut. If you have symptoms of SIBO, which can often be associated with tinnitus, too, consider eating a lower carb, low FODMAP diet, and try daily “intermittent fasting” which will allow your body to sweep bacteria out of the small intestine into the colon. People with SIBO have fewer “cleansing waves” than those with healthy guts, so compressing your food intake into two larger meals, spaced further apart, will allow your upper GI tract to become less of a feeding area for these misplaced gut microbes, and encourage them to seek their food sources further down, in the colon, where they belong.

Also, consider adding cultured foods like kefir, raw, organic sauerkraut, and yogurt to your diet, to displace less-friendly bacteria with healthy flora, to protect the gut wall, and nuture other beneficial strains in your upper and lower GI tract. Contrast these approaches to most standard dermatologists who prescribe gut-damaging antibiotics, and which would you rather choose? 🙂

If any of you have your own favorite approaches to acne control, I’d enjoy hearing from you in the comments section. Thanks!

Candida, SIBO and… Silver?

A brief bit of background: my mother took lots of antibiotics, from the 1950s onward, and was on Tetracyline when pregnant. I got my gut flora from her, as anyone would, but was born prematurely and spent 2 months in an isolette. This means I acquired the rest of my microbiome in a hospital, before heading home. I think it’s safe to say I’ve have had yeast issues for most of my life. My entire family did.

The standard medical attitude about candida continues to be “it doesn’t exist in anyone unless they are immune compromised”. My gut flora was damaged pre-birth, then I had a family doctor who prescribed antibiotics for a simple cough, or the sniffles, I’ve since been hit with Cipro and Levaquin (fluoroquinolone antibiotics) at least a dozen times, so from a modern understanding of gut-immune function, I am immune-compromised!

I got toenail fungus at an early age, developed sinus trouble (more antibiotics!) and have since read reputable sources saying most sinus issues are fungal. Candida? Maybe so, but the type of fungus is moot. Next I got asthma, seasonal allergies, then ulcerative colitis, then severe food intolerance. At no point along that path did any doctor say I needed to heal my microbiome, or go on a paleo diet, so if they didn’t understood something so basic, I can’t put much stock in their wholesale dismissal of candida overgrowth.

Here’s the good part — I’ve been getting better ever since I started paying attention to gut health. It’s simple. Lower carb is healing — sugar is bad. Probiotic foods are a “yes” — antibiotics are an emphatic “no” (unless utterly essential). It’s been a wonderful road back for me, with every single health condition.

I’ve recently discovered antibiotics very likely destroyed the fragile, butyrate-producing bacteria in my gut, and butyrate heals inflammation  — while also being anti-fungal. No wonder homemade sodium butyrate enemas have been so helpful for my ulcerative colitis flares. I believe butyrate could certainly help others with IBD, including Crohn’s disease. It may even play a role in protecting the upper gut (small intestine) from development of SIBO. Speaking of…

Early this week, a Monday, I’d just started a new job. I didn’t have time to fix my own lunch from home, so I had to fend for myself in the usual higher-carb, sugary restaurants. I found a beef roast with sides. The meat portion was tiny, covered with a sweet gravy. Roasted potatoes and green beans rounded it out, but that same sauce was all over the veggies. I was so hungry I ate every potato. Normally only eat about 3 oz of them a day. I’d been in good shape, gut-wise, for so long, I could afford to cheat, right? Wrong! By morning, I could tell I had yeast overgrowth. My gut had zero peristalsis, I had bad tinnitus, which for me is usually a sign of SIBO returning, my breathing was restricted, sinuses were inflamed, and energy was in the tank.

I’d had had such luck with yogurt, in recent weeks, I decided to eat two pints, the following day at work. Apparently the candida had done such a job slowing down my gut, the yogurt just sat there. Candida has been slowly digesting us since day one. I believe it uses “host manipulation“, which is what many successful parasites do. People with yeast overgrowth often crave sweets and alcohol. I know I have in the past, and I didn’t lose that until I started removing yeast from my body.

Hyphal Form Candida

It makes sense: if candida creates sweet tooths to feed itself, why wouldn’t it also emit chemicals to slow down gut transport, to more effectively eat our food? This may explain why so many of us are underweight, or constipated, and could be a strong hypothesis for alcoholism. Here’s a very interesting thread exploring a connection between SIBO and candida. Normally benign, its invasive (hyphal) form is thought to just be a symptom of dysbiosis. A healthy array of commensal bacteria should curb overgrowth. However, for those who’ve had hyphal form for decades, we need to deal with it.

I am hosting hookworm right now, for food intolerance, asthma, IBD, so I can’t take oregano oil, olive leaf, berberine, even peppermint, without killing them. Colloidal silver is an antibiotic, but it will just stun them for a few days.  Numerous articles discuss a rare condition called agyria, where people who consumed massive amounts of silver turned their skin a bluish tint. I have taken only 3 courses, a few weeks at a time, in the last 4 years. I’m not worried about changing color!

So back to the problem at hand, by the end of day 2 my entire back was sore, where it was nearly impossible to walk. I have a specific pull-pattern where one rib gets dislocated, and it happens most often when my gut is unhealthy. Lipopolysaccharide, a bacterial endotoxin, may be the root of this inflammation. That night, I simply couldn’t find any position to lie in, and insomnia made everything worse. I spiked a fever from the SIBO, which is rare for me, and my lungs felt like bronchitis was developing.

Most people would have gone to the doctor at this point, and been prescribed antibiotics, but I don’t tolerate most of them, and would rather use an antimicrobial that kills both bacteria and yeast.

The morning of day 3, I still had a fever, and started with 1 ounce of 500 ppm (parts per million) colloidal silver in a pint of distilled water, which makes it about 33 ppm. This is a safe level, in my opinion, especially since I take it very rarely. It has had a long history as an antibiotic before the modern pharma-industry developed conventional antibiotics. Here’s a study showing silver’s effectiveness against antibiotic-resistant strains. I’ve read other sources claiming it “smothers” both good and bad bugs. Its effect on candida is confirmed by several studies.

To deal with my lungs I used 30 ppm silver in a miniature glass spray bottle. 5 puffs every two hours. So how did it all go? Interestingly, the oral silver seemed to get my gut moving, and my stools were soft but formed. I’m thinking this relates to a lower yeast population in the gut. A few hours after starting inhalation, my lungs were clear, the fever broke, and I’m still feeling pretty good. I’ve read articles where doctors used CS in a nebulizer to treat people with AIDS-related lung infections, so this seems like a solid approach. It protects weak patients like me (who are immune compromised) from gut-damaging systemic antibiotics.

What’s my takeaway? Buying silver is expensive, and I normally make my own, using a cheap generator, that tests out about 17 ppm. The cost of home-brewed is pennies per pint. I plan to use the silver orally and as a spray mist only if needed, for the next few days, then I’ll go back to cultured foods like homemade kefir, raw sauerkraut. Silver is best used sparingly. I prefer adding healthy flora to my gut, not killing friend and foe alike. I also take Prescript Assist, VSL #3, and LifeStart powder now, as probiotics, plus an occasional butyrate enema. This is what works, and I’ll keep it up, but perhaps the moral to this story is, the next time I’m late for work, I’ll stop and cook my own, sugar-free, lower-carb lunch!

PS: for those interested in learning more about colloidal silver, here’s a great group on Facebook: Colloidal Silver, Pro & Con, where all points of view are appreciated. And keep in mind all the usual caveats apply: ask your doctor before trying any new therapy.